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This shift is underscored by recent findings that highlight the central role of context-dependent efficacy, whereby baseline nutrient status, genetic variability, and comorbid metabolic profiles critically determine clinical outcomes (Table 1

Address correspondence to: Julian Braun, Regenerative Immunology and Aging, BIH Center for Immunomics, Charit Universittsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany

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More in-depth research that clarifies the roles of these components of the GST-detoxification system are much needed, in order to produce compounds that have minimal side effects and high GST selectivity

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